Ultrasound increases nanoparticle delivery by reducing intratumoral pressure and increasing transport in epithelial and epithelial-mesenchymal transition tumors.

@article{Watson2012UltrasoundIN,
  title={Ultrasound increases nanoparticle delivery by reducing intratumoral pressure and increasing transport in epithelial and epithelial-mesenchymal transition tumors.},
  author={Katherine D. Watson and Chun-Yen Lai and Shengping Qin and Dustin E. Kruse and Yueh-Chen Lin and Jai Woong Seo and Robert Cardiff and Lisa M. Mahakian and Julie R. Beegle and Elizabeth S. Ingham and Fitz-Roy Curry and R. K. Reed and Katherine W. Ferrara},
  journal={Cancer research},
  year={2012},
  volume={72 6},
  pages={1485-93}
}
Acquisition of the epithelial-mesenchymal transition (EMT) tumor phenotype is associated with impaired chemotherapeutic delivery and a poor prognosis. In this study, we investigated the application of therapeutic ultrasound methods available in the clinic to increase nanotherapeutic particle accumulation in epithelial and EMT tumors by labeling particles with a positron emission tomography tracer. Epithelial tumors were highly vascularized with tight cell-cell junctions, compared with EMT… CONTINUE READING

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