Ultrasound for drug and gene delivery to the brain.

  title={Ultrasound for drug and gene delivery to the brain.},
  author={Kullervo Hynynen},
  journal={Advanced drug delivery reviews},
  volume={60 10},
Noninvasive, transient, and local image-guided blood-brain barrier disruption (BBBD) has been demonstrated with focused ultrasound exposure in animal models. Most studies have combined low pressure amplitude and low time average acoustic power burst sonications with intravascular injection of pre-formed micro-bubbles to produce BBBD without damage to the… CONTINUE READING