Ultrasound enhancement of thrombolysis and reperfusion in vitro.

  title={Ultrasound enhancement of thrombolysis and reperfusion in vitro.},
  author={David Harpaz and Xu fa Chen and Charles W. Francis and Victor J. Marder and Richard S. Meltzer},
  journal={Journal of the American College of Cardiology},
  volume={21 6},
OBJECTIVES The aims of this study were 1) to develop an in vitro flow system in which reperfusion mediated by ultrasound-accelerated thrombolysis could be studied, and 2) to test whether ultrasound-accelerated thrombolysis could hasten reperfusion in this system. BACKGROUND Ultrasound has been shown to increase tissue plasminogen activator (t-PA)-induced thrombolysis in vitro as assessed by radioactive fibrinogen release from labeled clots and in an animal in vivo model. METHODS To test… CONTINUE READING
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