Ultrasound enhanced antitumor activity of liposomal doxorubicin in mice.

@article{Hagtvet2011UltrasoundEA,
  title={Ultrasound enhanced antitumor activity of liposomal doxorubicin in mice.},
  author={Eirik Hagtvet and Tove Julie Evjen and Dag Rune Olsen and Sigrid L Fossheim and Esben A. Nilssen},
  journal={Journal of drug targeting},
  year={2011},
  volume={19 8},
  pages={701-8}
}
Liposomal encapsulation of doxorubicin (DXR) improves tumor accumulation and reduces adverse effects. One possible strategy for further optimization of this delivery technology would be to design the liposome carrier to release its content within the tumor tissue in response to specific stimuli such as ultrasound (US). In this study, the tumor uptake properties and therapeutic efficacy of 1,2 distearoyl-sn-glycero-3-phosphatidylethanolamine-based liposomes containing DXR were investigated in… CONTINUE READING