Ultrasound dose fractionation in sonodynamic therapy.

  title={Ultrasound dose fractionation in sonodynamic therapy.},
  author={Amir Hoshang Barati and Manijeh Mokhtari-Dizaji},
  journal={Ultrasound in medicine & biology},
  volume={36 6},
Sonodynamic therapy (SDT) is a new modality in cancer therapy and it is based on preferential uptake and/or retention of a sonosensitizing drug in tumor tissues and subsequent activation of the drug by ultrasound. The dose fractionation effect in radiation therapy has been known for more than a century, but it is not reported in SDT so far. In this study, the in vivo antitumor effect of the simultaneous dual-frequency ultrasound (1 MHz and 150 kHz) at low-level intensity (cumulative I(SATA) = 2… CONTINUE READING

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