Ultrasound biomicroscopy: a powerful tool probing murine lymph node size in vivo.

@article{Bosisio2009UltrasoundBA,
  title={Ultrasound biomicroscopy: a powerful tool probing murine lymph node size in vivo.},
  author={Matt{\'e}o R. Bosisio and Corentin Maisonneuve and Sylvie Gr{\'e}goire and Adrian Kettaneh and Christopher George Mueller and S. Lori Bridal},
  journal={Ultrasound in medicine & biology},
  year={2009},
  volume={35 7},
  pages={1209-16}
}
Invasive cell-counting in lymph node (LN) is the current reference to assess LN changes due to inflammation, immunodeficiency and cancer in murine models. This work evaluates whether ultrasound biomicroscopy (UBM) can measure LN size alterations noninvasively for a large range of sizes (0.1 mm3 to 22 mm3). Correlation was assessed (rho = 0.91, p < 0.0001) between invasive cell count and LN volume estimated with UBM (24, 2 to 28-week-old, C57BL/6 mice; 13 same-strain, transgenic mice presenting… CONTINUE READING