Ultrasound-assisted microbubbles gene transfer in tendons for gene therapy.

Abstract

Our study aimed at evaluating the use of ultrasound-assisted microbubbles gene transfer in mice Achilles tendons. Using a plasmid encoding luciferase gene, it was found that an efficient and stable gene expression for more than two weeks was obtained when tendons were injected with 10 microg of plasmid in the presence of 5x10(5) BR14 microbubbles with the… (More)
DOI: 10.1016/j.ultras.2009.09.035

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