Ultrasound as a method to enhance antitumor ability of oncolytic herpes simplex virus for head and neck cancer

@article{Okunaga2015UltrasoundAA,
  title={Ultrasound as a method to enhance antitumor ability of oncolytic herpes simplex virus for head and neck cancer},
  author={Shusuke Okunaga and Ayako Takasu and Noritoshi Meshii and Takeharu Imai and Masakazu Hamada and Soichi Iwai and Yoshiaki Yura},
  journal={Cancer Gene Therapy},
  year={2015},
  volume={22},
  pages={163-168}
}
Low-intensity ultrasound is a useful method to enhance the delivery of drugs to target cells via a range of mechanisms including the transient formation of micropores in the cell membrane, a process known as sonoporation. The effect of ultrasound on oncolytic herpes simplex virus type-1 (HSV-1) infection in oral squamous cell carcinoma (SCC) was examined. Human SCC cell line SAS and oncolytic HSV-1 RH2, which was deficient in the neurovirulent γ134.5 gene and exhibited cell fusion actions, were… CONTINUE READING

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