• Corpus ID: 51801380

Ultrasound accelerated synthesis of novel benzimidazole derived chalcones as glucosidases inhibitor and antimicrobial agents

@inproceedings{Meshram2016UltrasoundAS,
  title={Ultrasound accelerated synthesis of novel benzimidazole derived chalcones as glucosidases inhibitor and antimicrobial agents},
  author={Gangadhar Meshram and Vipul A. Vala and P. Wagh and Shruti S. Deshpande},
  year={2016}
}
A novel series of 3-substituted-1-[1-(toluene-4-sulfonyl)-1H-benzoimidazol-2-yl]-propen-1-one 3a-m have been synthesized by tosylation of benzimidazole chalcones 2a-m using ultrasound in lesser time with higher yields. All the synthesized compounds have been characterized by IR, H and C NMR, mass and elemental analysis in full accordance with their depicted structure. Biological evaluation of the compounds 3a-m reveals that compound 3f shows moderate inhibition of glucoamylase and compound 3i… 

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Benzimidazole is an important moiety from a medicinal chemistry perspective due to its various biological activities such as antimicrobial, anti-cancer, anti-diabetic, anti-Alzheimers, and

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