Ultrasound-accelerated immunoassay, as exemplified by enzyme immunoassay of choriogonadotropin.


The rate-limiting step in many solid-phase immunoassays is associated with the slow kinetics of binding of macro-molecular antigen and conjugate to the immobilized phase. We demonstrate that the use of ultrasonic energy to enhance mass transport across liquid/solid interfaces can dramatically accelerate antigen binding to immobilized antibodies. We use an… (More)


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@article{Chen1984UltrasoundacceleratedIA, title={Ultrasound-accelerated immunoassay, as exemplified by enzyme immunoassay of choriogonadotropin.}, author={R D Chen and Leiming Weng and N C Sizto and Beatriz Osorio and C J Hsu and R. P. Channing Rodgers and David J. Litman}, journal={Clinical chemistry}, year={1984}, volume={30 9}, pages={1446-51} }