Ultrasound-Triggered Drug Delivery for Breast Tumor Therapy Through iRGD-Targeted Paclitaxel-Loaded Liposome-Microbubble Complexes.

@article{Zhang2018UltrasoundTriggeredDD,
  title={Ultrasound-Triggered Drug Delivery for Breast Tumor Therapy Through iRGD-Targeted Paclitaxel-Loaded Liposome-Microbubble Complexes.},
  author={Jing Zhang and Song Wang and Zhiting Deng and Li Li and Guanghong Tan and Xin Lei Liu and Hairong Zheng and Fei Yan},
  journal={Journal of biomedical nanotechnology},
  year={2018},
  volume={14 8},
  pages={
          1384-1395
        }
}
Liposome-microbubble complexes (LMC) have become a promising therapeutic carrier for ultrasound-triggered local drug release. However, it is still desirable for the released drugs to be delivered to tumors as effectively as possible. Here, we fabricated iRGD-targeted paclitaxel-loaded liposome-microbubble complexes (iRGD-PTX-LMC) and investigated the feasibility of enhancing the local drug delivery to breast tumors by using these complexes along with ultrasound irradiation. Our results showed… CONTINUE READING
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