Ultrasound-Mediated Microbubble Destruction (UMMD) Facilitates the Delivery of CA19-9 Targeted and Paclitaxel Loaded mPEG-PLGA-PLL Nanoparticles in Pancreatic Cancer

@inproceedings{Xing2016UltrasoundMediatedMD,
  title={Ultrasound-Mediated Microbubble Destruction (UMMD) Facilitates the Delivery of CA19-9 Targeted and Paclitaxel Loaded mPEG-PLGA-PLL Nanoparticles in Pancreatic Cancer},
  author={Lingxi Xing and Qiusheng Shi and Kailiang Zheng and Ming Shen and Jing Ma and Fan Li and Yang Liu and Lizhou Lin and Wenzhi Tu and Yourong Duan and Lian-fang Du},
  booktitle={Theranostics},
  year={2016}
}
Pancreatic cancer, one of the most lethal human malignancies with dismal prognosis, is refractory to existing radio-chemotherapeutic treatment modalities. There is a critical unmet need to develop effective approaches, especially for targeted pancreatic cancer drug delivery. Targeted and drug-loaded nanoparticles (NPs) combined with ultrasound-mediated microbubble destruction (UMMD) have been shown to significantly increase the cellular uptake in vitro and drug retention in vivo, suggesting a… CONTINUE READING
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