Ultrasonic gene and drug delivery using eLiposomes.

  title={Ultrasonic gene and drug delivery using eLiposomes.},
  author={Marjan Javadi and William G. Pitt and Christopher M. Tracy and Jeffery R. Barrow and Barry M. Willardson and Jonathan M Hartley and Naakaii H Tsosie},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={167 1},
eLiposomes are liposomes encapsulating emulsions and therapeutics for targeted delivery. By applying ultrasound to eLiposomes, emulsion droplets can transform from liquid to gas and rupture the lipid bilayer of the eLiposome to release a drug or plasmid. In this study, perfluoropentane (PFC5) emulsions were encapsulated inside folated eLiposomes carrying a model drug (calcein) or a model GFP plasmid to examine the effects of a folate ligand, PFC5 emulsion and various ultrasonic acoustic… CONTINUE READING
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