Ultrasonic enhancement of antibiotic action on gram-negative bacteria.

  title={Ultrasonic enhancement of antibiotic action on gram-negative bacteria.},
  author={William G. Pitt and Michael O McBride and Jared K Lunceford and Randall J. Roper and Richard D. Sagers},
  journal={Antimicrobial agents and chemotherapy},
  volume={38 11},
The effect of gentamicin upon planktonic cultures of Pseudomonas aeruginosa, Escherichia coli, Staphylococcus epidermidis, and Staphylococcus aureus was measured with and without application of 67-kHz ultrasonic stimulation. The ultrasound was applied at levels that had no inhibitory or bactericidal activity against the bacteria. Measurements of the MIC and bactericidal activity of gentamicin against planktonic cultures of P. aeruginosa and E. coli demonstrated that simultaneous application of… CONTINUE READING

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