Ultrasonic assessment of hepatic blood flow as a marker of mouse hepatocarcinoma.

  title={Ultrasonic assessment of hepatic blood flow as a marker of mouse hepatocarcinoma.},
  author={Philippe Bonnin and Aude Villemain and François Vincent and Haythem Debbabi and Jean S{\'e}bastien Silvestre and Jean Olivier Contreres and Bernard I L{\'e}vy and G{\'e}rard Tobelem and Evelyne Dupuy},
  journal={Ultrasound in medicine & biology},
  volume={33 4},
Two-dimensional color-coded pulsed Doppler ultrasonography (US) with a 12-MHz linear transducer was used to follow tumor growth and neoangiogenesis development in 12 transgenic mice developing a whole liver hepatocellular carcinoma (HCC) induced by the expression of SV40-T antigen. In this model, male mice developed HCC at various temporal and histologic stages (hyperplastic, four-eight wk; nodular, 12 wk; diffuse carcinoma, 16-20 wk), whereas female mice remained tumor free. Seven age-matched… CONTINUE READING
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