Ultrashort antibacterial and antifungal lipopeptides.

  title={Ultrashort antibacterial and antifungal lipopeptides.},
  author={Arik Makovitzki and Dorit Avrahami and Yechiel Shai},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 43},
Host-defense cationic antimicrobial peptides ( approximately 12-50 aa long) play an essential protective role in the innate immune system of all organisms. Lipopeptides, however, are produced only in bacteria and fungi during cultivation, and they are composed of specific lipophilic moieties attached to anionic peptides (six to seven amino acids). Here we report the following. (i) The attachment of an aliphatic chain to otherwise inert, cationic D,L tetrapeptides endows them with potent… CONTINUE READING
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