Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase

@inproceedings{Xu2012UltrasensitiveRO,
  title={Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase},
  author={Yi-Fan Xu and Daniel Amador-Noguez and Marshall Reaves and Xiao-Jiang Feng and Joshua D. Rabinowitz},
  booktitle={Nature chemical biology},
  year={2012}
}
Anapleurosis is the filling of the tricarboxylic acid cycle with four-carbon units. The common substrate for both anapleurosis and glucose phosphorylation in bacteria is the terminal glycolytic metabolite phosphoenolpyruvate (PEP). Here we show that Escherichia coli quickly and almost completely turns off PEP consumption upon glucose removal. The resulting buildup of PEP is used to quickly import glucose if it becomes available again. The switch-like termination of anapleurosis results from… CONTINUE READING
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