Ultrasensitive pheromone detection by mammalian vomeronasal neurons

@article{LeindersZufall2000UltrasensitivePD,
  title={Ultrasensitive pheromone detection by mammalian vomeronasal neurons},
  author={Trese Leinders-Zufall and Andrew P Lane and Adam C. Puche and Weidong Ma and Milos V. Novotny and Michael T Shipley and Frank Zufall},
  journal={Nature},
  year={2000},
  volume={405},
  pages={792-796}
}
The vomeronasal organ (VNO) is a chemoreceptive organ that is thought to transduce pheromones into electrical responses that regulate sexual, hormonal and reproductive function in mammals. The characteristics of pheromone signal detection by vomeronasal neurons remain unclear. Here we use a mouse VNO slice preparation to show that six putative pheromones evoke excitatory responses in single vomeronasal neurons, leading to action potential generation and elevated calcium entry. The detection… CONTINUE READING
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