Ultrasensitive assessment of residual low-level HIV viremia in HAART-treated patients and risk of virological failure.

@article{Maggiolo2012UltrasensitiveAO,
  title={Ultrasensitive assessment of residual low-level HIV viremia in HAART-treated patients and risk of virological failure.},
  author={Franco Maggiolo and Annapaola Callegaro and Giuliana Cologni and Claudia Bernardini and Daniela Velenti and Giampietro Gregis and Giampaolo Quinzan and Laura Soavi and Nathalie Iannotti and Emanuele Malfatto and Sebastiano Leone},
  journal={Journal of acquired immune deficiency syndromes},
  year={2012},
  volume={60 5},
  pages={
          473-82
        }
}
BACKGROUND Low-level viremia (LLV) is measurable, with enhanced assays, in many subjects with HIV RNA levels <50 copies per milliliter. The clinical consequences of LLV are unknown. METHODS In a prospective study in HIV-1-infected adults, HIV RNA levels were determined with an ultrasensitive test (3 copies/mL) based on a real time polymerase chain reaction. The primary end point was to evaluate LLV prediction of virological failure, defined as a confirmed plasma HIV RNA level >50 copies per… CONTINUE READING
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