Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid

@article{Saijo2017UltrasensitiveAS,
  title={Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid},
  author={Eri Saijo and Bernardino Ghetti and Gianluigi Zanusso and Adrian L. Oblak and Jennifer L. Furman and Marc I Diamond and Allison M. Kraus and Byron Caughey},
  journal={Acta Neuropathologica},
  year={2017},
  volume={133},
  pages={751-765}
}
The diagnosis and treatment of diseases involving tau-based pathology such as Alzheimer disease and certain frontotemporal dementias is hampered by the inability to detect pathological forms of tau with sufficient sensitivity, specificity and practicality. In these neurodegenerative diseases, tau accumulates in self-seeding filaments. For example, Pick disease (PiD) is associated with frontotemporal degeneration and accumulation of 3-repeat (3R) tau isoforms in filaments constituting Pick… CONTINUE READING

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