Ultramicronized palmitoylethanolamide reduces inflammation an a Th1-mediated model of colitis

@article{Impellizzeri2015UltramicronizedPR,
  title={Ultramicronized palmitoylethanolamide reduces inflammation an a Th1-mediated model of colitis},
  author={Daniela Impellizzeri and Michela Campolo and Rosanna Di Paola and Giuseppe Bruschetta and Daniela De Stefano and Emanuela Esposito and Salvatore Cuzzocrea},
  journal={European Journal of Inflammation},
  year={2015},
  volume={13},
  pages={14 - 31}
}
Inflammatory bowel diseases are idiopathic relapsing disorders characterized by chronic inflammation of the intestinal tract. The aim of the present study was to examine the effect of ultramicronized palmitoylethanolamide (PEAultra), underlining its correlation with PPARα and TLR4; in particular, we aimed at evaluating its anti-inflammatory effect in mice subjected to experimental colitis. Colitis was induced in mice by intracolonic instillation of dinitrobenzene sulfonic acid (DNBS), PEAultra… 

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