Ultramicronized palmitoylethanolamide reduces inflammation an a Th1-mediated model of colitis

  title={Ultramicronized palmitoylethanolamide reduces inflammation an a Th1-mediated model of colitis},
  author={Daniela Impellizzeri and Michela Campolo and Rosanna Di Paola and Giuseppe Bruschetta and Daniela De Stefano and Emanuela Esposito and Salvatore Cuzzocrea},
  journal={European Journal of Inflammation},
  pages={14 - 31}
Inflammatory bowel diseases are idiopathic relapsing disorders characterized by chronic inflammation of the intestinal tract. The aim of the present study was to examine the effect of ultramicronized palmitoylethanolamide (PEAultra), underlining its correlation with PPARα and TLR4; in particular, we aimed at evaluating its anti-inflammatory effect in mice subjected to experimental colitis. Colitis was induced in mice by intracolonic instillation of dinitrobenzene sulfonic acid (DNBS), PEAultra… 

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Palmitoylethanolamide and Related ALIAmides for Small Animal Health: State of the Art

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Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis.

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Effects of zileuton, a new 5-lipoxygenase inhibitor, in experimentally induced colitis in rats

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Glucocorticoid-induced leucine zipper is protective in Th1-mediated models of colitis.

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Effects of Palmitoylethanolamide on Signaling Pathways Implicated in the Development of Spinal Cord Injury

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Increased mucosal nitric oxide production in ulcerative colitis is mediated in part by the enteroglial‐derived S100B protein

  • C. CirilloG. Sarnelli R. Cuomo
  • Biology, Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2009
Enteroglial‐derived S100B up‐regulation in UC participates in NO production, involving RAGE in a steroid insensitive pathway and was significantly inhibited by both specific anti‐RAGE and anti‐S100B blocking antibodies.

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