Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia.

@article{Rauova2005UltralargeCO,
  title={Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia.},
  author={Lubica Rauova and M. Poncz and Steven E. McKenzie and Michael P. Reilly and Gowthami Morey Arepally and John W. Weisel and Chandrasekaran Nagaswami and Douglas B Cines and Bruce S. Sachais},
  journal={Blood},
  year={2005},
  volume={105 1},
  pages={131-8}
}
Heparin-induced thrombocytopenia and thrombosis (HITT) is a severe complication of heparin therapy caused by antibodies to complexes between unfractionated heparin (UFH) and platelet factor 4 (PF4) that form over a narrow molar range of reactants and initiate antibody-induced platelet activation. We observed that UFH and tetrameric PF4 formed ultralarge (> 670 kDa) complexes (ULCs) only over a narrow molar range with an optimal ratio of PF4 to heparin of approximately 1:1. These ULCs were… CONTINUE READING
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