Ultrahigh-resolution optical coherence tomography.

  title={Ultrahigh-resolution optical coherence tomography.},
  author={Wolfgang Drexler},
  journal={Journal of biomedical optics},
  volume={9 1},
  • W. Drexler
  • Published 2004
  • Physics
  • Journal of biomedical optics
In the past two decades, optical coherence tomography (OCT) has been established as an adjunct diagnostic technique for noninvasive, high-resolution, cross-sectional imaging in a variety of medical fields. The rapid development of ultrabroad bandwidth light sources has recently enabled a significant improvement in OCT imaging resolution, demonstrating the potential of OCT to accomplish its original goal of performing noninvasive optical biopsies, i.e., the in vivo visualization of… 

Optical coherence tomography: Technology and applications

  • W. Drexler
  • Medicine
    2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC
  • 2013
Extensions of OCT are under development that should provide enhanced contrast or non-invasive depth resolved functional imaging of the investigated tissue, including extraction of birefringent, spectroscopic, blood flow or physiologic tissue information, which should improve image contrast and enable the differentiation and early detection of pathologies via localized functional state.

Optical Coherence Tomography for Three-Dimensional Imaging in the Biomedical Field: A Review

Optical coherence tomography (OCT) has become a novel approach to noninvasive imaging in the past three decades, bringing a significant potential to biological research and medical biopsy in situ,

Optical coherence tomography in biomedical research

An outline of the state of the art and novel trends of innovative OCT approaches in biomedical research in which the main focus is on applications in fundamental research and pre-clinical utilization is given.

State-of-the-art retinal optical coherence tomography

[Methodological advancements. Ultrahigh-resolution OCT].

  • W. Drexler
  • Medicine
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • 2004
UHR OCT allows detection of intraretinal changes that can be used for diagnosis of retinal disease in its early stages when treatment is most effective and irreversible damage can be prevented or delayed and provides a better understanding of the pathogenesis of several macular pathologies.

Optical coherence tomography.

Imaging Motion: A Comprehensive Review of Optical Coherence Tomography Angiography.

  • W. Choi
  • Medicine
    Advances in experimental medicine and biology
  • 2021
The potential and challenge of OCTA for clinical settings are shown with outcomes of human studies and its scan protocols and post-processing algorithms for acquisition of angiography are shown.

Optical coherence tomography—current technology and applications in clinical and biomedical research

Optical coherence tomography is a noninvasive imaging technique that provides real-time two- and three-dimensional images of scattering samples with micrometer resolution that has proven its value as a tool for developmental biology.

High-resolution extended source optical coherence tomography.

A novel imaging system that achieves enhanced sensitivity without axial resolution degradation by the use of a spectrally encoded extended source (SEES) technique; it allows larger sample power without exceeding the maximum permissible exposure (MPE).

Improved image speckle noise reduction and novel dispersion cancellation in Optical Coherence Tomography

Two novel speckle noise reduction algorithms based on interval type II fuzzy sets has been developed to improve the quality of the OCT images and a novel even-order dispersion cancellation interferometry via a linear, classical interferometer has been development.



Ultrahigh resolution optical biopsy with endoscopic optical coherence tomography.

The ability of ultrahigh resolution endoscopic OCT to image tissue morphology at an unprecedented resolution in vivo advances the development of OCT as a potential imaging tool for the early detection of neoplastic changes in biological tissue.

Optical coherence tomography - principles and applications

There have been three basic approaches to optical tomography since the early 1980s: diffraction tomography, diffuse optical tomography and optical coherence tomography (OCT). Optical techniques are

Ultrahigh resolution Fourier domain optical coherence tomography.

Visualization of intra-retinal layers, especially the inner and outer segment of the photoreceptor layer, obtained by FDOCT was comparable to that, accomplished by ultrahigh resolution time domain OCT, despite an at least 40 times higher data acquisition speed of FD OCT.

New Technology for High‐Speed and High‐Resolution Optical Coherence Tomography a

Recent advances in OCT technology are described including the application of short pulse solid state lasers based on Ti: Al2O3 and Cr: Mg2SiO4 to enable high-resolution, high-speed imaging as well as the development of OCT catheter/endoscope delivery to permit imaging of internal organ systems.

Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy.

OCT can be used where standard excisional biopsy is hazardous or impossible, to reduce sampling errors associated with excisionality, and to guide interventional procedures, and its potential biomedical and clinical applications are described.

In vivo ultrahigh-resolution optical coherence tomography.

To overcome depth-of-field limitations the authors perform zone focusing and image fusion to construct a tomogram with high transverse resolution throughout the image depth, which is to their knowledge the highest longitudinal resolution demonstrated to date for in vivo OCT imaging.

Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography.

In vitro ophthalmic ultrahigh-resolution OCT imaging reveals retinal morphology with unprecedented detail, and the specific assignment of OCT signal patterns to retinal substructures provides a basis for improved interpretation of in vivoOCT tomograms of high clinical relevance.

Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography.

Ultrahigh-resolution ophthalmic OCT enables unprecedented visualization of intraretinal morphologic features and therefore has the potential to contribute to a better understanding of ocular pathogenesis, as well as to enhance the sensitivity and specificity for early ocular diagnosis and to monitor the efficacy of therapy.