Ultrafine carbon particles induce apoptosis and proliferation in rat lung epithelial cells via specific signaling pathways both using EGF-R.

@article{Sydlik2006UltrafineCP,
  title={Ultrafine carbon particles induce apoptosis and proliferation in rat lung epithelial cells via specific signaling pathways both using EGF-R.},
  author={Ulrich Sydlik and Katrin Bierhals and Maria Soufi and Josef Abel and Roel P F Schins and Klaus Unfried},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={291 4},
  pages={L725-33}
}
Apoptosis and proliferation are important causes of adverse health effects induced by inhaled ultrafine particles. The molecular mechanisms of particle cell interactions mediating these end points are therefore a major topic of current particle toxicology and molecular preventive medicine. Initial studies revealed that ultrafine particles induce apoptosis and proliferation in parallel in rat lung epithelial cells, dependent on time and dosage. With these end points, two antagonistic reactions… CONTINUE READING