Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier

@inproceedings{Sofueva2011UltrafineAB,
  title={Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier},
  author={Sevil Sofueva and Fekret Osman and Alexander Lorenz and Roland Steinacher and Stefania Castagnetti and Jennifer Ledesma and Matthew C Whitby},
  booktitle={Nucleic acids research},
  year={2011}
}
Most DNA double-strand breaks (DSBs) in S- and G2-phase cells are repaired accurately by Rad51-dependent sister chromatid recombination. However, a minority give rise to gross chromosome rearrangements (GCRs), which can result in disease/death. What determines whether a DSB is repaired accurately or inaccurately is currently unclear. We provide evidence that suggests that perturbing replication by a non-programmed protein-DNA replication fork barrier results in the persistence of replication… CONTINUE READING

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