Ultrafiltration vs equilibrium dialysis for determination of free fraction.

Abstract

The analytical basis of membrane separation in determining plasma free drug concentrations is developed from consideration of the generalised ideal mass action and conservation laws applied to thermodynamic states of differing component volumes. The intuitively surprising theoretical independence of free drug concentration with changing fractional volume of… (More)

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@article{Bowers1984UltrafiltrationVE, title={Ultrafiltration vs equilibrium dialysis for determination of free fraction.}, author={Warner F. Bowers and Stephanie Fulton and J. Thompson}, journal={Clinical pharmacokinetics}, year={1984}, volume={9 Suppl 1}, pages={49-60} }