Ultraconserved elements in insect genomes: a highly conserved intronic sequence implicated in the control of homothorax mRNA splicing.

@article{Glazov2005UltraconservedEI,
  title={Ultraconserved elements in insect genomes: a highly conserved intronic sequence implicated in the control of homothorax mRNA splicing.},
  author={Evgeny A. Glazov and Michael Pheasant and Elizabeth A McGraw and Gill Bejerano and John S. Mattick},
  journal={Genome research},
  year={2005},
  volume={15 6},
  pages={800-8}
}
Recently, we identified a large number of ultraconserved (uc) sequences in noncoding regions of human, mouse, and rat genomes that appear to be essential for vertebrate and amniote ontogeny. Here, we used similar methods to identify ultraconserved genomic regions between the insect species Drosophila melanogaster and Drosophila pseudoobscura, as well as the more distantly related Anopheles gambiae. As with vertebrates, ultraconserved sequences in insects appear to occur primarily in intergenic… CONTINUE READING

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