Ultraconserved Elements in the Human Genome

@article{Bejerano2004UltraconservedEI,
  title={Ultraconserved Elements in the Human Genome},
  author={G. Bejerano and Michael Pheasant and I. Makunin and S. Stephen and W. Kent and J. Mattick and D. Haussler},
  journal={Science},
  year={2004},
  volume={304},
  pages={1321 - 1325}
}
  • G. Bejerano, Michael Pheasant, +4 authors D. Haussler
  • Published 2004
  • Biology, Medicine
  • Science
  • There are 481 segments longer than 200 base pairs (bp) that are absolutely conserved (100% identity with no insertions or deletions) between orthologous regions of the human, rat, and mouse genomes. Nearly all of these segments are also conserved in the chicken and dog genomes, with an average of 95 and 99% identity, respectively. Many are also significantly conserved in fish. These ultraconserved elements of the human genome are most often located either overlapping exons in genes involved in… CONTINUE READING
    1,464 Citations

    Topics from this paper.

    Multiple organism algorithm for finding ultraconserved elements
    • 6
    • Highly Influenced
    • PDF
    Human Genome Ultraconserved Elements Are Ultraselected
    • 224
    • PDF
    Ultraconserved Elements Between the Genomes of the Plants Arabidopsis thaliana and Rice
    • 27
    Identification and characterization of new long conserved noncoding sequences in vertebrates
    • 30
    • Highly Influenced
    • PDF
    Highly Conserved Non-Coding Sequences Are Associated with Vertebrate Development
    • 909
    • PDF

    References

    SHOWING 1-10 OF 59 REFERENCES
    Evolutionarily conserved sequences on human chromosome 21.
    • 98
    • PDF