Ultraconserved Elements in the Human Genome

  title={Ultraconserved Elements in the Human Genome},
  author={G. Bejerano and Michael Pheasant and I. Makunin and S. Stephen and W. Kent and J. Mattick and D. Haussler},
  pages={1321 - 1325}
  • G. Bejerano, Michael Pheasant, +4 authors D. Haussler
  • Published 2004
  • Biology, Medicine
  • Science
  • There are 481 segments longer than 200 base pairs (bp) that are absolutely conserved (100% identity with no insertions or deletions) between orthologous regions of the human, rat, and mouse genomes. Nearly all of these segments are also conserved in the chicken and dog genomes, with an average of 95 and 99% identity, respectively. Many are also significantly conserved in fish. These ultraconserved elements of the human genome are most often located either overlapping exons in genes involved in… CONTINUE READING
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