Ultraconservation identifies a small subset of extremely constrained developmental enhancers

  title={Ultraconservation identifies a small subset of extremely constrained developmental enhancers},
  author={Axel Visel and Shyam Prabhakar and Jennifer A. Akiyama and Malak I. Shoukry and Keith D. Lewis and Amy B Holt and Ingrid Plajzer-Frick and Veena Afzal and Edward M. Rubin and Len A. Pennacchio},
  journal={Nature Genetics},
Extended perfect human-rodent sequence identity of at least 200 base pairs (ultraconservation) is potentially indicative of evolutionary or functional uniqueness. We used a transgenic mouse assay to compare the embryonic enhancer activity of 231 noncoding ultraconserved human genome regions with that of 206 extremely conserved regions lacking ultraconservation. Developmental enhancers were equally prevalent in both populations, suggesting instead that ultraconservation identifies a small… CONTINUE READING
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  • N Ahituv
  • PLoS Biol. 5,
  • 2007

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