Ultrabithorax is required for membranous wing identity in the beetle Tribolium castaneum

  title={Ultrabithorax is required for membranous wing identity in the beetle Tribolium castaneum},
  author={Yoshinori Tomoyasu and Scott R. Wheeler and Robin E. Denell},
The two pairs of wings that are characteristic of ancestral pterygotes (winged insects) have often undergone evolutionary modification. In the fruitfly, Drosophila melanogaster, differences between the membranous forewings and the modified hindwings (halteres) depend on the Hox gene Ultrabithorax (Ubx). The Drosophila forewings develop without Hox input, while Ubx represses genes that are important for wing development, promoting haltere identity. However, the idea that Hox input is important… 

Ultrabithorax Is a Micromanager of Hindwing Identity in Butterflies and Moths

Using CRISPR targeted mutagenesis to generate Ubx loss-of-function somatic mutations in two nymphalid butterflies and a pyralid moth yielded hindwing-to-forewing transformations, confirming Ubx is a master selector of lepidopteran hindwing identity and suggesting it acts on many gene regulatory networks involved in wing development and patterning.

Flight or protection: the genes Ultrabithorax and apterous in the determination of membranous and sclerotized wings in insects

The sclerotizing properties of ap demonstrated in beetles and cockroaches suggest that the origin of this function goes back to the emergence of Neoptera, in the mid Devonian.

Hox genes are essential for the development of eyespots in Bicyclus anynana butterflies.

Antp and Ubx have acquired a novel role in promoting the development of a new set of serial homologs, the eyespot patterns, in both forewings and hindwings of B. anynana butterflies, using CRISPR-Cas9 to target both genes.

Evolution of nubbin function in hemimetabolous and holometabolous insect appendages.

Hox and wings.

  • J. Deutsch
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2005
The function of thoracic Hox genes in the beetle Tribolium castaneum is examined using classical genetics, transgenesis and RNAi to find out what happens to the homeotic transformation of the second pair of dorsal appendages, the wings, into elytra.

Early Development and Diversity of Gryllus Appendages

Cricket hind leg can serve as an exceptional model for combined studies of both tissue growth and segmental patterning during embryonic leg development and formulates a general framework that can be used for future studies on the development and diversification of insect appendages.

Tergal and pleural wing‐related tissues in the German cockroach and their implication to the evolutionary origin of insect wings

It is demonstrated that B. germanica possesses two distinct tissues in their wingless segments, one with tergal and one with pleural nature, that might be evolutionarily related to wings, indicating a more complex evolutionary history of the tissues that contributed to the emergence of insect wings.



Ultrabithorax function in butterfly wings and the evolution of insect wing patterns

Molecular and genetic analysis of the Tribolium Ultrabithorax ortholog, Ultrathorax

Phenotypic analysis of mutant variants of the Ultrathorax (Utx) gene, and its location within the beetle HOM-C, strongly supports Utx being the Tribolium ortholog of Ubx.

Molecular characterization of Cephalothorax, the Tribolium ortholog of Sex combs reduced

Sex combs reduced (Scr), a Hox gene located in the Antennapedia complex of Drosophila melanogaster, is required for the proper development of the labial and first thoracic segments and cloned and characterized the Tribolium ortholog of Scr (TcScr).

Evolution of homeotic gene regulation and function in flies and butterflies

The difference in larval limb number between these insects results from striking changes in BX-C gene regulation in the butterfly abdomen, and it is deduced that the wing-patterning genes regulated by Ultrabithorax have diverged in the course of butterfly and fly evolution.

Sequence of the Tribolium castaneum homeotic complex: the region corresponding to the Drosophila melanogaster antennapedia complex.

The region containing the homeotic selector genes required for proper development of the head and anterior thorax, which is the counterpart of the ANTC in Drosophila, is sequenced.

A deficiency of the homeotic complex of the beetle Tribolium

IN Drosophila, the establishment of regional commitments along most of the anterior/posterior axis of the developing embryo depends on two clusters of homeotic genes: the Antennapedia complex (ANT-C)

The expression and function of the achaete-scute genes in Tribolium castaneum reveals conservation and variation in neural pattern formation and cell fate specification

Analysis of the Tribolium ac/sc genes indicates significant plasticity in gene number, expression and function, and implicates these modifications in the evolution of arthropod neural development.

Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere.

The results suggest that Ubx, and Hox genes in general, independently and selectively regulate genes that act at many levels of regulatory hierarchies to shape the differential development of serially homologous structures.