Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice☆


Bone is a complex material with a hierarchical multi-scale organization from the molecule to the organ scale. The genetic bone disease, osteogenesis imperfecta, is primarily caused by mutations in the collagen type I genes, resulting in bone fragility. Because the basis of the disease is molecular with ramifications at the whole bone level, it provides a… (More)
DOI: 10.1016/j.bone.2012.03.007


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