Ultra-small-sample molecular structure detection using microslot waveguide nuclear spin resonance.

@article{Maguire2007UltrasmallsampleMS,
  title={Ultra-small-sample molecular structure detection using microslot waveguide nuclear spin resonance.},
  author={Yael Maguire and Isaac L. Chuang and Shuguang Zhang and Neil Gershenfeld},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 22},
  pages={9198-203}
}
We here report on the design of a planar microslot waveguide NMR probe with an induction element that can be fabricated at scales from centimeters to nanometers to allow analysis of biomolecules at nano- or picomole quantities, reducing the required amount of materials by several orders of magnitude. This device demonstrates the highest signal-to-noise ratio for a planar detector to date, measured by using the anomeric proton signal from a 15.6-nmol sample of sucrose. This probe had a linewidth… CONTINUE READING