Ultra-short-acting beta-blockade: a comparison with conventional beta-blockade.

  title={Ultra-short-acting beta-blockade: a comparison with conventional beta-blockade.},
  author={Charles S. Reilly and Margaret Wood and R P Koshakji and Alastair J. J. Wood},
  journal={Clinical pharmacology and therapeutics},
  volume={38 5},
Esmolol is a beta 1-selective adrenoceptor blocker that is rapidly metabolized by blood and liver esterases. The beta-receptor and hemodynamic effects of esmolol were determined in a group of 12 healthy men and were compared with those induced by both oral and intravenous propranolol. Esmolol was rapidly effective in inducing at least 90% of steady-state beta-blockade within 5 minutes of either initiating or changing the esmolol infusion rate. More importantly, when esmolol infusion was… CONTINUE READING

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