Ultra-sensitive FISH is a useful tool for studying chronic HIV-1 infection.

@article{Deichmann1997UltrasensitiveFI,
  title={Ultra-sensitive FISH is a useful tool for studying chronic HIV-1 infection.},
  author={Martin Deichmann and Michael D. Bentz and Rainer Haas},
  journal={Journal of virological methods},
  year={1997},
  volume={65 1},
  pages={
          19-25
        }
}
Using an ultra-sensitive fluorescence in situ hybridization (FISH) protocol, integration sites of the human immunodeficiency virus-1 (HIV-1) were mapped in two model cell lines for chronic HIV infection. In the promonocytic cell line U1/HIV-1, the two integrated copies of proviral HIV-DNA were located on the short arm of one copy of chromosome X (band Xp21) and on a rearranged chromosome 6. In the T-cell line 8E5/LAV, the single copy of proviral HIV-DNA was integrated into chromosomal bands… CONTINUE READING
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