Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein.

@article{Tsai2009UltralowDN,
  title={Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein.},
  author={R-Y Tsai and Y-H Tai and J-I Tzeng and C-H Cherng and C-C Yeh and C Wong},
  journal={Neuroscience},
  year={2009},
  volume={164 2},
  pages={435-43}
}
Pertussis toxin (PTX) treatment results in ADP-ribosylation of Gi-protein and thus in disruption of mu-opioid receptor signal transduction and loss of the antinociceptive effect of morphine. We have previously demonstrated that pretreatment with ultra-low dose naloxone preserves the antinociceptive effect of morphine in PTX-treated rats. The present study further examined the effect of ultra-low dose naloxone on mu-opioid receptor signaling in PTX-treated rats and the underlying mechanism. Male… CONTINUE READING

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Ultralow-dose naloxone restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in PTX-treated rats

  • RY sai, FL Jang, YH Tai, SL Lin, CH Shen, CS Wong
  • Neuropsychopharmacology
  • 2008
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