Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein.

Abstract

Pertussis toxin (PTX) treatment results in ADP-ribosylation of Gi-protein and thus in disruption of mu-opioid receptor signal transduction and loss of the antinociceptive effect of morphine. We have previously demonstrated that pretreatment with ultra-low dose naloxone preserves the antinociceptive effect of morphine in PTX-treated rats. The present study… (More)
DOI: 10.1016/j.neuroscience.2009.08.015

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@article{Tsai2009UltralowDN, title={Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein.}, author={R-Y Tsai and Y-H Tai and J-I Tzeng and C-H Cherng and C-C. Yeh and C-S Wong}, journal={Neuroscience}, year={2009}, volume={164 2}, pages={435-43} }