Ultra high performance liquid chromatography tandem mass spectrometric detection in clinical analysis of simvastatin and atorvastatin.

@article{Novkov2009UltraHP,
  title={Ultra high performance liquid chromatography tandem mass spectrometric detection in clinical analysis of simvastatin and atorvastatin.},
  author={Lucie Nov{\'a}kov{\'a} and Hana Vl{\vc}kov{\'a} and Dalibor {\vS}at{\'i}nsk{\'y} and Petr Sad{\'i}lek and Dagmar Solichov{\'a} and Milan Blaha and Vladim{\'i}r Bl{\'a}ha and Petr Solich},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2009},
  volume={877 22},
  pages={2093-103}
}
Simvastatin and atorvastatin belong to the group of hypolipidemic drugs, more exactly to the second generation of inhibitors of microsomal 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. They induce a significant reduction in total cholesterol, low-density lipoprotein cholesterol and plasma triglycerides, therefore they are widely used in the treatment of hypercholesterolemia even of its severe form-familiar hypercholesterolemia. Simvastatin and atorvastatin as the most widely used… CONTINUE READING

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