Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

@article{Lffler2011Ulk1mediatedPO,
  title={Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.},
  author={Antje S. L{\"o}ffler and Sebastian Alers and Alexandra M Dieterle and Hildegard Keppeler and Mirita Franz-Wachtel and Mondira Kundu and David G Campbell and Sebastian Wesselborg and Dario R Alessi and Bj{\"o}rn Stork},
  journal={Autophagy},
  year={2011},
  volume={7 7},
  pages={696-706}
}
Unc-51-like kinase 1 (Ulk1) plays a central role in autophagy induction. It forms a stable complex with Atg13 and focal adhesion kinase (FAK) family interacting protein of 200 kDa (FIP 200). This complex is negatively regulated by the mammalian target of rapamycin complex 1 (mTORC1) in a nutrient-dependent way. AMP-activated protein kinase (AMPK), which is activated by LKB1/Strad/Mo25 upon high AMP levels, stimulates autophagy by inhibiting mTORC1. Recently, it has been described that AMPK and… CONTINUE READING

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