Ulinastatin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of AMPK/NF-κB pathway.

@article{Li2015UlinastatinIT,
  title={Ulinastatin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of AMPK/NF-κB pathway.},
  author={Wuquan Li and Xiaochen Qiu and He Zhong Jiang and Yan Zhi and Jinfeng Fu and Jun Liu},
  journal={International immunopharmacology},
  year={2015},
  volume={29 2},
  pages={560-567}
}
BACKGROUND Ulinastatin (ULI), a serine protease inhibitor, had been widely used as a drug for patients with acute inflammatory disorders. However, evidence regarding the anti-inflammatory effect of ulinastatin was still lacking. In this study, we investigated the protective mechanisms of ULI in LPS-induced acute lung injury (ALI). METHODS ALI was induced in mice by intratracheal instillation of LPS. The cells in the bronchoalveolar lavage fluid (BALF) were counted. The degree of animal lung… CONTINUE READING

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