Ulinastatin activates haem oxygenase 1 antioxidant pathway and attenuates allergic inflammation.

Abstract

BACKGROUND AND PURPOSE Ulinastatin (UTI), a serine protease inhibitor, was recently found to have an anti-inflammatory action. However, the mechanisms mediating this anti-inflammatory effect are not well understood. This study tested the hypothesis that UTI suppresses allergic inflammation by inducing the expression of haem oxygenase 1 (HO1). EXPERIMENTAL… (More)
DOI: 10.1111/bph.12780

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