Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

@article{Sadlack1993UlcerativeCD,
  title={Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene},
  author={Benjamin Sadlack and H William Merz and Hubert Schorle and Anneliese Schimpl and Ivan Horak},
  journal={Cell},
  year={1993},
  volume={75},
  pages={253-261}
}
Mice deficient for interleukin-2 develop normally during the first 3-4 weeks of age. However, later on they become severely compromised, and about 50% of the animals die between 4 and 9 weeks after birth. Of the remaining mice, 100% develop an inflammatory bowel disease with striking clinical and histological similarity to ulcerative colitis in humans. The alterations of the immune system are characterized by a high number of activated T and B cells, elevated immunoglobulin secretion, anti… CONTINUE READING
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