Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway.

@article{Fujiwara2008UlcerativeCC,
  title={Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway.},
  author={Ichiro Fujiwara and Masakazu Yashiro and Naoshi Kubo and Kiyoshi Maeda and Kosei Hirakawa},
  journal={Diseases of the colon and rectum},
  year={2008},
  volume={51 9},
  pages={1387-94}
}
PURPOSE Patients with ulcerative colitis have a high risk for the development of colorectal cancer. To understand the molecular mechanisms of the carcinogenesis process of ulcerative colitis-associated colorectal cancer, the genetic alterations in inflamed or neoplastic colon epithelium in ulcerative colitis were analyzed. METHODS Fifty-seven patients with ulcerative colitis were enrolled in this study. Specimens were obtained from the patients randomly at six colonic sites. Each patient was… CONTINUE READING