Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase.

@article{Guo2008UgeneAN,
  title={Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase.},
  author={Chunguang Guo and Xiaodong Zhang and Stephen P. Fink and Petra Platzer and Keith Wilson and James K. V. Willson and Zhenghe Wang and Sanford D Markowitz},
  journal={Cancer research},
  year={2008},
  volume={68 15},
  pages={
          6118-26
        }
}
Expression microarrays identified a novel transcript, designated as Ugene, whose expression is absent in normal colon and colon adenomas, but that is commonly induced in malignant colon cancers. These findings were validated by real-time PCR and Northern blot analysis in an independent panel of colon cancer cases. In addition, Ugene expression was found to be elevated in many other common cancer types, including breast, lung, uterus, and ovary. Immunofluorescence of V5-tagged Ugene revealed it… CONTINUE READING

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