Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

@inproceedings{Nillegoda2010Ubr1AU,
  title={Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins},
  author={Nadinath B. Nillegoda and Maria A. Theodoraki and Atin K. Mandal and Katie J. Mayo and Hongkai Ren and Rasheda Sultana and Kenneth Q Wu and J. L. Johnson and Douglas M. Cyr and Avrom J. Caplan},
  booktitle={Molecular biology of the cell},
  year={2010}
}
Quality control systems facilitate polypeptide folding and degradation to maintain protein homeostasis. Molecular chaperones promote folding, whereas the ubiquitin/proteasome system mediates degradation. We show here that Saccharomyces cerevisiae Ubr1 and Ubr2 ubiquitin ligases promote degradation of unfolded or misfolded cytosolic polypeptides. Ubr1 also catalyzes ubiquitinylation of denatured but not native luciferase in a purified system. This activity is based on the direct interaction of… CONTINUE READING

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