Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23

@article{Cohen2003Ubp3RA,
  title={Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23},
  author={Micka{\"e}l M Cohen and Françoise Stutz and Na{\"i}ma Belgareh and Rosine Haguenauer-Tsapis and Catherine Dargemont},
  journal={Nature Cell Biology},
  year={2003},
  volume={5},
  pages={661-667}
}

• Mickaël M Cohen, Françoise Stutz, +2 authors Catherine Dargemont
• Published 2003 in Nature Cell Biology
• DOI:10.1038/ncb1003

Ubiquitination is important for a broad array of cellular functions. Although reversal of this process, de-ubiquitination, most probably represents an important regulatory step contributing to cellular homeostasis, the specificity and properties of de-ubiquitination enzymes remain poorly understood. Here, we show that the Saccharomyces cerevisiae ubiquitin protease Ubp3 requires an additional protein, Bre5, to form an active de-ubiquitination complex that cleaves ubiquitin from specific… CONTINUE READING

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