Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23

  title={Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23},
  author={Micka{\"e}l M Cohen and Françoise Stutz and Na{\"i}ma Belgareh and Rosine Haguenauer-Tsapis and Catherine Dargemont},
  journal={Nature Cell Biology},
Ubiquitination is important for a broad array of cellular functions. Although reversal of this process, de-ubiquitination, most probably represents an important regulatory step contributing to cellular homeostasis, the specificity and properties of de-ubiquitination enzymes remain poorly understood. Here, we show that the Saccharomyces cerevisiae ubiquitin protease Ubp3 requires an additional protein, Bre5, to form an active de-ubiquitination complex that cleaves ubiquitin from specific… CONTINUE READING
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