Ubisol-Aqua: coenzyme Q10 prevents antiretroviral toxic neuropathy in an in vitro model.

@article{Cherry2010UbisolAquaCQ,
  title={Ubisol-Aqua: coenzyme Q10 prevents antiretroviral toxic neuropathy in an in vitro model.},
  author={Catherine Louise Cherry and Masqura Mobarok and Steven L. Wesselingh and Randi Fain and Shelley B. Weinstock and Gilda Tachedjian and Seema Srivastava and David P Tyssen and Jonathan D. Glass and David James Hooker},
  journal={Current HIV research},
  year={2010},
  volume={8 3},
  pages={232-9}
}
BACKGROUND Peripheral neuropathy is the dose-limiting toxicity of stavudine and didanosine (nucleoside analogs used in HIV treatment) and is attributed to mitochondrial toxicity from these drugs. Acetyl L-carnitine (ALC) and co-enzyme Q(10) are proposed as neuropathy treatments, but evidence to support these is limited. METHODS We examined ALC and a water-soluble formulation of co-enzyme Q(10) (H(Q)O) for the prevention of d4T and ddI neurotoxicity using cultured fetal rat DRG as an in vitro… CONTINUE READING