Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria.

@article{Turrens1985UbisemiquinoneIT,
  title={Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria.},
  author={Julio F. Turrens and A. Louis Alexandre and Albert Lester Lehninger},
  journal={Archives of biochemistry and biophysics},
  year={1985},
  volume={237 2},
  pages={
          408-14
        }
}
Much evidence indicates that superoxide is generated from O2 in a cyanide-sensitive reaction involving a reduced component of complex III of the mitochondrial respiratory chain, particularly when antimycin A is present. Although it is generally believed that ubisemiquinone is the electron donor to O2, little experimental evidence supporting this view has been reported. Experiments with succinate as electron donor in the presence of antimycin A in intact rat heart mitochondria, which contain… CONTINUE READING
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