Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

@article{Theurillat2014UbiquitylomeAI,
  title={Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer},
  author={J P Theurillat and Namrata D Udeshi and Wesley J. Errington and Tanya Svinkina and Sylvan C. Baca and Marius Pop and Peter J. Wild and Mirjam Blattner and Anna C. Groner and Mark A. Rubin and Holger Moch and Gilbert G. Priv{\'e} and Steven A. Carr and Levi A. Garraway},
  journal={Science},
  year={2014},
  volume={346},
  pages={85-89}
}
Cancer genome characterization has revealed driver mutations in genes that govern ubiquitylation; however, the mechanisms by which these alterations promote tumorigenesis remain incompletely characterized. Here, we analyzed changes in the ubiquitin landscape induced by prostate cancer–associated mutations of SPOP, an E3 ubiquitin ligase substrate-binding protein. SPOP mutants impaired ubiquitylation of a subset of proteins in a dominant-negative fashion. Of these, DEK and TRIM24 emerged as… CONTINUE READING
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