Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress

@article{Peng2017UbiquitylationOP,
  title={Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress},
  author={Hong Peng and Jiao L Yang and Guangyi Li and Qing You and Wen Ling Han and Tianrang Li and Daming Gao and Xiaoduo Xie and Byung-hoon Lee and Juan Du and Jian Hou and Tao Zhang and H. S. Rao and Ying Huang and Qinrun Li and Rong Zeng and Lijian Hui and Hongyan Wang and Qin Xia and Xuemin Zhang and Yongning He and M. Asaliaru Komatsu and Ivan Dikic and Daniel Finley and Ronggui Hu},
  journal={Cell Research},
  year={2017},
  volume={27},
  pages={657-674}
}
Alterations in cellular ubiquitin (Ub) homeostasis, known as Ub stress, feature and affect cellular responses in multiple conditions, yet the underlying mechanisms are incompletely understood. Here we report that autophagy receptor p62/sequestosome-1 interacts with E2 Ub conjugating enzymes, UBE2D2 and UBE2D3. Endogenous p62 undergoes E2-dependent ubiquitylation during upregulation of Ub homeostasis, a condition termed as Ub+ stress, that is intrinsic to Ub overexpression, heat shock or… CONTINUE READING
Highly Cited
This paper has 26 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 66 references

Guidelines for the use and interpretation of assays for monitoring autophagy

DJ Klionsky, K Abdelmohsen, A Abe
Autophagy • 2016

p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome.

Proceedings of the National Academy of Sciences of the United States of America • 2016

Similar Papers

Loading similar papers…