Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms.

@article{Drogen2006UbiquitylationOC,
  title={Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms.},
  author={Frank van Drogen and Olle Sangfelt and Aljona Malyukova and Ludmila V. Matskova and Elizabeth S. Yeh and Anthony R. Means and S. I. Reed},
  journal={Molecular cell},
  year={2006},
  volume={23 1},
  pages={37-48}
}
Cyclin E, an activator of cyclin-dependent kinase 2 (Cdk2), is targeted for proteasomal degradation by phosphorylation-dependent multiubiquitylation via the ubiquitin ligase SCF(hCdc4). SCF ubiquitin ligases are composed of a core of conserved subunits and one variable subunit (an F box protein) involved in substrate recognition. We show here that multiubiquitylation of cyclin E requires the sequential function of two distinct splice variant isoforms of the F box protein hCdc4 known as alpha… CONTINUE READING

From This Paper

Topics from this paper.
51 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Similar Papers

Loading similar papers…